Position Summary:

The research scientist will be involved in conducting immune-oncology research programs directed at identifying new therapeutic targets and development drug development programs in cancer around these targets. The candidate will write scientific publications, grant and patent applications. The responsibilities of this position include developing and executing cell-based assays, in vitro, ex vivo and in vivo to characterize biological mechanisms of action of novel immunotherapeutic product candidates for the treatment of cancer. The candidate will be aligned with four fundamental pillars of BTI’s entrepreneurial corporate culture: 1) Be bold and decisive, 2) Never give up, 3) Be solution-oriented, and 4) Do the impossible.

Responsibilities:

• Experimental Design: Generate and test novel experimental hypotheses to advance discovery-based R&D at BTI. Propose controlled designs capable of robustly testing respective hypotheses to draw conclusions relevant to drug development research.
• Data analysis: Utilize established and novel methods to analyze data. Data types will include but are not limited to flow cytometry results, high-throughput sequencing, protein biochemistry assays, and histopathology.
• Data communication and reporting: Provide detailed reports of experimental results. Generate figures, presentations and publications to communicate results with scientific community, investors, and collaborators. Support the development of peer reviewed scientific publications, patents and grants relevant to ongoing research.
• Laboratory Procedures: Perform various standard experimental assays including quantitative real-time PCR, Western blot, flow cytometry, and ELISA. Work in sterile conditions to conduct cell culture experiments and maintain the growth of cell lines. Express and purify recombinant protein. Collect and analyze generated data.
• Personnel Training: Training of BTI personnel on laboratory upkeep, experimental assays and research projects. Guide the personnel resourcing of projects and tasks.
• Animal Procedures: Conduct various IACUC approved laboratory animal procedures and techniques for BTI’s projects including but not limited to basic rodent handling, oral gavage, intraperitoneal injection, blood collection, and euthanasia. Interact with animal facility personnel to maintain organization and compliance of animal facilities. Will design new animal studies for projects related to therapeutic efficacy or mechanisms of action of new drugs for autoimmune diseases.
• Teamwork: Work independently and collaboratively in a matrixed environment. Be able to successfully work with other BTI team members in experiments.
• Regulatory Compliance: Support regulatory compliance efforts as instructed by the senior leadership in accordance with IACUC, IBC, and IRB protocols. Implement, organize and maintain regulatory compliance records.
• Record keeping: Keep detailed records of all activities, record these activities in ASANA, Google Drive, laboratory notebook, the BTI’s Colony Management System (CMS), and Labkey. Provide weekly updates of the BTI research progress to the Scientific Director, and BTI team. Maintains confidentiality of all data, information and knowledge.
• Maintain the confidentiality of all company deliberations and plans.
• Any new responsibilities or changes in the reporting structure as directed by the executive leadership.
• Act in accordance with Company’s policies.