BioTherapeutics | 1800 Kraft Dr., Suite 200, Blacksburg, VA, 24060


Safer and more effective nutritional products from nature’s innovation

Punicic Acid (PUA)

Why PUA?
  • Punicic acid (PUA) has demonstrated effectiveness in decreasing gut inflammation and improving digestive health.
What is PUA?
  • PUA is a dietary lipid found in pomegranate seed oil (PSO).

BTI Discoveries

  • Oral supplementation of PSO and its predominant bioactive constituent has demonstrated efficacy in suppressing gut inflammation.
  • The health benefits of PUA resemble those of conjugated linoleic acid (CLA).
  • PSO ameliorates intestinal inflammation in mouse models of Inflammatory Bowel Disease (IBD) and necrotizing enterocolitis (NEC).

Disease Activity Level graph

Innovative Pathway - NLRX1

  • PUA binds to nucleotide-binding oligomerization domain, leucine rich repeat containing X1 (NLRX1).
  • Involved in down-regulating inflammation during bacterial and viral exposure, acute non-infectious colitis, colorectal cancer and chronic pulmonary disease.
  • Demonstrated convergence between NLRX1, antimicrobial peptide production and altered microbiome ecology.
  • Loss of NLRX1 during colitis causes severe mucosal damage.


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