BioTherapeutics Inc

Modeling-Enabled Systems Nutritional Immunology.

Verma M., R. Hontecillas, V. Abedi, A. Leber, N.T. Juni, C. Philipson, A. Carbo, J. Bassaganya-Riera
Frontiers in Nutrition, section Nutritional Immunology 2016 Feb 16;3
PMID: 26909350

Modeling-Enabled Characterization of Novel NLRX1 Ligands.

Lu P, Hontecillas R, Abedi V, Kale S, Leber A, Heltzel C, Langowski M, Godfrey V, Philipson C, Tubau-Juni N, Carbo A, Girardin S, Uren A, Bassaganya-Riera J.
PLoS One 2015 Dec 29;10(12)
PMID: 26714018

Modulation of inflammation and immunity by dietary conjugated linoleic acid.

Viladomiu M, Hontecillas R, Bassaganya-Riera J.
Eur J Pharmacol 2015 May 15
PMID: 25987426

Zinc deficiency alters host response and pathogen virulence in a mouse model of enteroaggregative Escherichia coli-induced diarrhea.

Bolick DT, Kolling GL, Moore JH 2nd, de Oliveira LA, Tung K, Philipson C, Viladomiu M, Hontecillas R, Bassaganya-Riera J, Guerrant RL.
Gut Microbes 2014 Jan 1;5(5):618-27
PMID: 25483331

Elevated CD8 T cell responses in type 1 diabetes patients to a 13 amino acid coeliac-active peptide from a-gliadin.

Barbeau WE, Hontecillas R, Horne W, Carbo A, Koch MH, Bassaganya-Riera J.
Clin Exp Immunol 2014 Feb 1;175(2):167-71
PMID: 24016298

Expression of PPAR y in intestinal epithelial cells is dispensable for the prevention of colitis by dietary abscisic acid.

Hontecillas R, Bassaganya-Riera J.
ESPEN J 2012 Oct 1;7(5):e189-e195
PMID: 23814701

Preventive and prophylactic mechanisms of action of pomegranate bioactive constituents.

Viladomiu M, Hontecillas R, Lu P, Bassaganya-Riera J.
Evid Based Complement Alternat Med 2013 Jan 1
PMID: 23737845

Nutritional protective mechanisms against gut inflammation.

Viladomiu M, Hontecillas R, Yuan L, Lu P, Bassaganya-Riera J.
J Nutr Biochem 2013 Jun 1;24(6):929-39
PMID: 23541470

Enteroaggregative Escherichia coli strain in a novel weaned mouse model: exacerbation by malnutrition, biofilm as a virulence factor and treatment by nitazoxanide.

Bolick DT, Roche JK, Hontecillas R, Bassaganya-Riera J, Nataro JP, Guerrant RL.
J Med Microbiol 2013 Jun 1;62(Pt 6):896-905
PMID: 23475903

Dietary abscisic acid ameliorates influenza-virus-associated disease and pulmonary immunopathology through a PPAR?-dependent mechanism.

Hontecillas R, Roberts PC, Carbo A, Vives C, Horne WT, Genis S, Velayudhan B, Bassaganya-Riera J.
J Nutr Biochem 2013 Jun 1;24(6):1019-27
PMID: 22995385

Pomegranate seed oil reduces intestinal damage in a rat model of necrotizing enterocolitis.

Coursodon-Boyiddle CF, Snarrenberg CL, Adkins-Rieck CK, Bassaganya-Riera J, Hontecillas R, Lawrence P, Brenna JT, Jouni ZE, Dvorak B.
Am J Physiol Gastrointest Liver Physiol 2012 Sep 1;303(6):G744-51
PMID: 22821948

Conjugated linoleic acid modulates immune responses in patients with mild to moderately active Crohn's disease.

Bassaganya-Riera J, Hontecillas R, Horne WT, Sandridge M, Herfarth HH, Bloomfeld R, Isaacs KL.
Clin Nutr 2012 Oct 1;31(5):721-7
PMID: 22521469

Immunoregulatory mechanisms underlying prevention of colitis-associated colorectal cancer by probiotic bacteria.

Bassaganya-Riera J, Viladomiu M, Pedragosa M, De Simone C, Hontecillas R.
PLoS One 2012 Jan 1;7(4)
PMID: 22511958

Probiotic bacteria produce conjugated linoleic acid locally in the gut that targets macrophage PPAR y to suppress colitis.

Bassaganya-Riera J, Viladomiu M, Pedragosa M, De Simone C, Carbo A, Shaykhutdinov R, Jobin C, Arthur JC, Corl BA, Vogel H, Storr M, Hontecillas R.
PLoS One 2012 Feb 21;7(2)
PMID: 22363592

Dietary a-eleostearic acid ameliorates experimental inflammatory bowel disease in mice by activating peroxisome proliferator-activated receptor-y.

Lewis SN, Brannan L, Guri AJ, Lu P, Hontecillas R, Bassaganya-Riera J, Bevan DR.
PLoS One 2011 Aug 31;6(8)
PMID: 21904603

Activation of PPARy and o by dietary punicic acid ameliorates intestinal inflammation in mice.

Bassaganya-Riera J, DiGuardo M, Climent M, Vives C, Carbo A, Jouni ZE, Einerhand AW, O'Shea M, Hontecillas R.
Br J Nut 2011 Sep 1;106(6):878-86
PMID: 21736821

Soluble fibers and resistant starch ameliorate disease activity in interleukin-10-deficient mice with inflammatory bowel disease.

Bassaganya-Riera J, DiGuardo M, Viladomiu M, de Horna A, Sanchez S, Einerhand AW, Sanders L, Hontecillas R.
J Nutr 2011 Jul 1;141(7):1318-25
PMID: 21562241

Pomegranate seed oil, a rich source of punicic acid, prevents diet-induced obesity and insulin resistance in mice.

Bassaganya-Riera J, Zondag GC, Romijn JA, Havekes LM, Voshol PJ.
Food Chem Toxicol 2011 Jan 1;49(6):1426-30

Suppression of intestinal inflammation and inflammation-driven colon cancer in mice by dietary sphingomyelin: importance of peroxisome proliferator-activated receptor ? expression.

Mazzei JC, Zhou H, Brayfield BP, Hontecillas R, Bassaganya-Riera J, Schmelz EM.
J Nutr Biochem 2011 Dec 1;22(12):1160-71

Treatment of Obesity-Related Complications with Novel Classes of Naturally Occurring PPAR Agonists.

Bassaganya-Riera J, Guri AJ, Hontecillas R.
J Obes 2011 Jan 1
PMID: 21253508

T cell PPAR? is required for the anti-inflammatory efficacy of abscisic acid against experimental IBD.

Guri AJ, Evans NP, Hontecillas R, Bassaganya-Riera J.
J Nutr Biochem 2011 Sep 1;22(9):812-9
PMID: 21109419

Abscisic acid regulates inflammation via ligand-binding domain-independent activation of peroxisome proliferator-activated receptor gamma.

Bassaganya-Riera J, Guri AJ, Lu P, Climent M, Carbo A, Sobral BW, Horne WT, Lewis SN, Bevan
J Biol Chem 2011 Jan 28;286(4):2504-16
PMID: 21088297

Systemic effects of white adipose tissue dysregulation and obesity-related inflammation.

Guri AJ, Bassaganya-Riera J.
Obesity (Silver Spring) 2011 Jan 1;19(4):689-700
PMID: 20930712

The role of T cell PPAR gamma in mice with experimental inflammatory bowel disease.

Guri AJ, Mohapatra SK, Horne WT 2nd, Hontecillas R, Bassaganya-Riera J.
BMC Gastroenterol 2010 Jun 10;10
PMID: 20537136

Molecular modeling of lanthionine synthetase component C-like protein 2: a potential target for the discovery of novel type 2 diabetes prophylactics and therapeutics.

Lu P, Bevan DR, Lewis SN, Hontecillas R, Bassaganya-Riera J.
J Mol Model 2011 Jan 1;17(3):543-53
PMID: 20512604

Dietary conjugated linoleic acid and n-3 polyunsaturated fatty acids in inflammatory bowel disease.

Bassaganya-Riera J, Hontecillas R.
Curr Opin Clin Nutr Metab Care 2010 Sep 1;13(5):569-73

Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice.

Fu Z, Zhang W, Zhen W, Lum H, Nadler J, Bassaganya-Riera J, Jia Z, Wang Y, Misra H, Liu D.
Endocrinology 2010 Jan 1;151(7):3026-37
PMID: 20484465

Abscisic acid synergizes with rosiglitazone to improve glucose tolerance and down-modulate macrophage accumulation in adipose tissue: possible action of the cAMP/PKA/PPAR ? axis.

Guri AJ, Hontecillas R, Bassaganya-Riera J.
Clin Nutr 2010 Oct 1;29(5):646-53
PMID: 20207056

Abscisic acid ameliorates atherosclerosis by suppressing macrophage and CD4+ T cell recruitment into the aortic wall.

Guri AJ, Misyak SA, Hontecillas R, Hasty A, Liu D, Si H, Bassaganya-Riera J.
J Nutr Biochem 2010 Jan 1;21(12):1178-85
PMID: 20092994

Conjugated linoleic acid ameliorates inflammation-induced colorectal cancer in mice through activation of PPARgamma.

Evans NP, Misyak SA, Schmelz EM, Guri AJ, Hontecillas R, Bassaganya-Riera J.
J Nutr. 2010 Mar 1;140(3):515-21

Mechanisms of action and medicinal applications of abscisic Acid.

Bassaganya-Riera J, Skoneczka J, Kingston DG, Krishnan A, Misyak SA, Guri AJ, Pereira A, Carter AB, Minorsky P, Tumarkin R, Hontecillas R.
Curr Med Chem 2010 Jan 1;17(5):467-78
PMID: 20015036

Green tea extract decreases muscle pathology and NF-kappaB immunostaining in regenerating muscle fibers of mdx mice.

Evans NP, Call JA, Bassaganya-Riera J, Robertson JL, Grange RW.
Clin Nutr 2010 Jun 1;29(3):391-8
PMID: 19897286

Activation of PPAR gamma and alpha by punicic acid ameliorates glucose tolerance and suppresses obesity-related inflammation.

Hontecillas R, O'Shea M, Einerhand A, Diguardo M, Bassaganya-Riera J.
J Am Coll Nutr 2009 Apr 1;28(2):184-95

Toxicological evaluation of pomegranate seed oil.

Meerts IA, Verspeek-Rip CM, Buskens CA, Keizer HG, Bassaganya-Riera J, Jouni ZE, van Huygevoort AH, van Otterdijk FM, van de Waart EJ.
Food Chem Toxicol 2009 Jun 1;47(6):1085-92
PMID: 19425183

PPAR gamma is highly expressed in F4/80(hi) adipose tissue macrophages and dampens adipose-tissue inflammation.

Bassaganya-Riera J, Misyak S, Guri AJ, Hontecillas R.
Cell Immunol 2009 May 6;258(2):138-46
PMID: 19423085

Dietary modulators of peroxisome proliferator-activated receptors: implications for the prevention and treatment of metabolic syndrome.

Guri AJ, Hontecillas R, Bassaganya-Riera J.
J Nutrigenet Nutrigenomics 2008 Feb 20;1(3):126-35
PMID: 19776622

Dietary modulation of inflammation-induced colorectal cancer through PPARy.

Carter AB, Misyak SA, Hontecillas R, Bassaganya-Riera J.
PPAR 2009 Jan 1
PMID: 19390648

Dietary modulation of inflammation-induced colorectal cancer through PPAR?.

Carter AB, Misyak SA, Hontecillas R, Bassaganya-Riera J.
PPAR Res 2009 Jan 1
PMID: 19390648

Catalpic acid decreases abdominal fat deposition, improves glucose homeostasis and upregulates PPAR alpha expression in adipose tissue.

Hontecillas R, Diguardo M, Duran E, Orpi M, Bassaganya-Riera J.
Clin Nutr 2008 Oct 1;27(5):764-72
PMID: 18778878

Dietary modulators of peroxisome proliferator-activated receptors: implications for the prevention and treatment of metabolic syndrome.

Guri AJ, Hontecillas R, Bassaganya-Riera J.
J Nutrigenet Nutrigenomics 200819776622 Jan 1;1(3):126-35

Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue.

Guri AJ, Hontecillas R, Ferrer G, Casagran O, Wankhade U, Noble AM, Eizirik DL, Ortis F, Cnop M, Liu D, Si H, Bassaganya-Riera J.
J Nutr Biochem 2008 Apr 1;19(4):216-28
PMID: 17618105

Arachidonic acid-and docosahexaenoic acid-enriched formulas modulate antigen-specific T cell responses to influenza virus in neonatal piglets.

Bassaganya-Riera J, Guri AJ, Noble AM, Reynolds KA, King J, Wood CM, Ashby M, Rai D, Hontecillas R.
Am J Clin Nutr 2007 Mar 1;85(3):824-36
PMID: 17344506

Peroxisome proliferator-activated receptors: bridging metabolic syndrome with molecular nutrition.

Guri AJ, Hontecillas R, Bassaganya-Riera J.
Clin Nutr. 2006 Dec 1;25(6):871-85
PMID: 17052808

Dietary abscisic acid ameliorates glucose tolerance and obesity-related inflammation in db/db mice fed high-fat diets.

Guri AJ, Hontecillas R, Si H, Liu D, Bassaganya-Riera J.
Clin Nutr. 2007 Feb 1;26(1):107-16
PMID: 17000034

CLA and n-3 PUFA differentially modulate clinical activity and colonic PPAR-responsive gene expression in a pig model of experimental IBD.

Bassaganya-Riera J, Hontecillas R.
Clin Nutr. 2006 Jun 1;25(3):454-65
PMID: 16698153

Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease.

Bassaganya-Riera J, Reynolds K, Martino-Catt S, Cui Y, Hennighausen L, Gonzalez F, Rohrer J, Benninghoff AU, Hontecillas R.
Gastroenterology. 2004 Sep 1;127(3):777-91
PMID: 15362034

Effects of dietary conjugated linoleic acid in nursery pigs of dirty and clean environments on growth, empty body composition, and immune competence.

Bassaganya-Riera J, Hontecillas-Magarzo R, Bregendahl K, Wannemuehler MJ, Zimmerman DR.
J Anim Sci. 2001 Mar 1;79(3):714-21
PMID: 11263832

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