Publications
Modeling the role of lanthionine synthetase C-like 2 (LANCL2) in the modulation of immune responses to H. pylori infection.
Leber, A., J. Bassaganya-Riera, N. Tubau-Juni, V. Zoccoli-Rodriguez, M. Viladomiu, V. Abedi, P. Lu, and R. Hontecillas
Plos One
Jan 1;In Press
An N,N-bis(benzimidazolylpicolinoyl)piperazine (BT-11): A Novel Lanthionine Synthetase C-like 2-Based Therapeutic for Inflammatory Bowel Disease
Adria Carbo, Richard D. Gandour, Raquel Hontecillas, Noah Philipson, Aykut Uren, and Josep Bassaganya-Riera
Journal of Medicinal Chemistry
2016 Nov 4
Translating nutritional immunology into drug development for inflammatory bowel disease
Leber, A., R. Hontecillas, N. Tubau-Juni, and J. Bassaganya-Riera
Current Opinion in Gatroenterology
2016 Jan 1;In Press.
Exploratory Studies With BT-11: A Proposed Orally Active Therapeutic for Crohn's Disease
Bissel P, Boes K, Hinckley J, Jortner BS, Magnin-Bissel G, Werre SR, Ehrich M, Carbo A, Philipson C, Hontecillas R, Philipson N, Gandour RD, Bassaganya-Riera J.
Int J Toxicol
2016 May 26
PMID: 27230993
Exploratory studies with BT-11: A proposed orally active therapeutic for Crohn’s disease.
Bissel, P., K. Boes, J. Hinckley, B.S. Jortner, G. Magnin-Bissel, S.R. Were, M. Ehrich, A. Carbo, C.W. Philipson, R. Hontecillas, N. Philipson, R.D. Gandour, and J. Bassaganya-Riera
International Journal of Toxicology
2016 Apr 1
PMID: In Press
NLRX1 Suppresses Tumorigenesis and Attenuates Histiocytic Sarcoma through the Negative Regulation of NF-kB Signaling
Coutermarch-Ott, S., A. Simmons, V. Capria, T. LeRoith, J. E. Wilson, B. Heid, C.W. Philipson, Q. Qin, R. Hontecillas, J. Bassaganya-Riera, J.P.Y. Ting, N. Dervisis, I.C. Allen
Oncotarget
2016 Apr 1
PMID: In Press
Bistability analyses of CD4+ T follicular helper and regulatory cells during Helicobacter pylori infection
Leber, A., V. Abedi, R. Hontecillas, M. Viladomiu, S. Hoops, S. Ciupe, J. Caughman, T. Andrew, J. Bassaganya-Riera
Journal of Theoretical Biology
2016 Apr 1
PMID: In Press
Modeling-Enabled Characterization of Novel NLRX1 Ligands.
Lu P, Hontecillas R, Abedi V, Kale S, Leber A, Heltzel C, Langowski M, Godfrey V, Philipson C, Tubau-Juni N, Carbo A, Girardin S, Uren A, Bassaganya-Riera J.
PLoS One
2015 Dec 29;10(12)
PMID: 26714018
Goals in Nutrition Science 2015-2020.
Allison DB, Bassaganya-Riera J, Burlingame B, Brown AW, le Coutre J, Dickson SL, van Eden W, Garssen J, Hontecillas R, Khoo CS, Knorr D, Kussmann M, Magistretti PJ, Mehta T, Meule A, Rychlik M, Vögele C.
Front Nutr
Sep 8;2(26)
PMID: 26442272
Modeling the Regulatory Mechanisms by Which NLRX1 Modulates Innate Immune Responses to Helicobacter pylori Infection.
Philipson CW, Bassaganya-Riera J, Viladomiu M, Kronsteiner B, Abedi V, Hoops S, Michalak P, Kang L, Girardin SE, Hontecillas R.
PLoS One
2015 Sep 14;10(9)
PMID: 26367386
Phosphorylation of PPARy Affects the Collective Motions of the PPARy-RXRa-DNA Complex.
Lemkul JA, Lewis SN, Bassaganya-Riera J, Bevan DR.
PLoS One
May 8;10(5)
PMID: 25954810
Pharmacophore modeling improves virtual screening for novel peroxisome proliferator-activated receptor-gamma ligands.
Lewis SN, Garcia Z, Hontecillas R, Bassaganya-Riera J, Bevan DR.
J Comput Aided Mol Des
2015 May 1;29(5):421-39
PMID: 25616366
Emerging significance of NLRs in inflammatory bowel disease.
Davis BK, Philipson C, Hontecillas R, Eden K, Bassaganya-Riera J, Allen IC.
Inflamm Bowel Dis
2014 Dec 1;20(12):2412-32
PMID: 25153506
Preclinical studies of amixicile, a systemic therapeutic developed for treatment of Clostridium difficile infections that also shows efficacy against Helicobacter pylori.
Hoffman PS, Bruce AM, Olekhnovich I, Warren CA, Burgess SL, Hontecillas R, Viladomiu M, Bassaganya-Riera J, Guerrant RL, Macdonald TL.
Antimicrob Agents Chemother
2014 Aug 1;58(8):4703-12
PMID: 24890599
Lanthionine synthetase component C-like protein 2: a new drug target for inflammatory diseases and diabetes.
Lu P, Hontecillas R, Philipson CW, Bassaganya-Riera J.
Curr Drug Targets
2014 Jun 1;15(6):565-72
PMID: 24628287
Stopping anti-TNF agents in patients with Crohn's disease in remission: is it a feasible long-term strategy?
Sorrentino D, Nash P, Viladomiu M, Hontecillas R, Bassaganya-Riera J.
Inflamm Bowel Dis
2014 Apr 1;20(4):757-66
PMID: 24572206
Translational research and efficacy of biologics in Crohn's disease: a cautionary tale.
Auer K, Trachter R, Van den Bogaerde J, Bassaganya-Riera J, Sorrentino D.
Expert Rev Clin Immunol
2014 Feb 1;10(2):219-29
PMID: 24410538
Systems modeling of molecular mechanisms controlling cytokine-driven CD4+ T cell differentiation and phenotype plasticity.
Carbo A, Hontecillas R, Kronsteiner B, Viladomiu M, Pedragosa M, Lu P, Philipson CW, Hoops S, Marathe M, Eubank S, Bisset K, Wendelsdorf K, Jarrah A, Mei Y, Bassaganya-Riera J.
PLoS Comput Biol
2013 Apr 1;9(4)
PMID: 23592971
Modeling the role of peroxisome proliferator-activated receptor y and microRNA-146 in mucosal immune responses to Clostridium difficile.
Viladomiu M, Hontecillas R, Pedragosa M, Carbo A, Hoops S, Michalak P, Michalak K, Guerrant RL, Roche JK, Warren CA, Bassaganya-Riera J.
PLoS One
2012 Jan 1;7(10)
PMID: 23071818
Computational modeling-based discovery of novel classes of anti-inflammatory drugs that target lanthionine synthetase C-like protein 2.
Lu P, Hontecillas R, Horne WT, Carbo A, Viladomiu M, Pedragosa M, Bevan DR, Lewis SN, Bassaganya-Riera J.
PLoS One
Jan 1;7(42012)
PMID: 22509338
Abscisic acid regulates inflammation via ligand-binding domain-independent activation of peroxisome proliferator-activated receptor gamma.
Bassaganya-Riera J, Guri AJ, Lu P, Climent M, Carbo A, Sobral BW, Horne WT, Lewis SN, Bevan
J Biol Chem
2011 Jan 28;286(4):2504-16
PMID: 21088297
Immunoregulatory mechanisms of macrophage PPAR-? in mice with experimental inflammatory bowel disease.
Hontecillas R, Horne WT, Climent M, Guri AJ, Evans C, Zhang Y, Sobral BW, Bassaganya-Riera J
Mucosal Immuno
2011 Jan 1;4(3):304-13
PMID: 21068720
Gene regulatory network reveals oxidative stress as the underlying molecular mechanism of type 2 diabetes and hypertension.
Jesmin J, Rashid MS, Jamil H, Hontecillas R, Bassaganya-Riera J
BMC Med Genomic
2010 Oct 13
PMID: PMID: 20942928
PPAR-gamma activation as an anti-inflammatory therapy for respiratory virus infections.
Bassaganya-Riera J, Song R, Roberts PC, Hontecillas R.
Viral Immunol
2010 Aug 1;23(4):343-52
PMID: 20712478
The human-bacterial pathogen protein interaction networks of Bacillus anthracis, Francisella tularensis, and Yersinia pestis.
Dyer MD, Neff C, Dufford M, Rivera CG, Shattuck D, Bassaganya-Riera J, Murali TM, Sobral BW.
PLoS One
2010 Aug 9;5(8)
PMID: 20711500
The role of T cell PPAR gamma in mice with experimental inflammatory bowel disease.
Guri AJ, Mohapatra SK, Horne WT 2nd, Hontecillas R, Bassaganya-Riera J.
BMC Gastroenterol
2010 Jun 10;10
PMID: 20537136
Molecular modeling of lanthionine synthetase component C-like protein 2: a potential target for the discovery of novel type 2 diabetes prophylactics and therapeutics.
Lu P, Bevan DR, Lewis SN, Hontecillas R, Bassaganya-Riera J.
J Mol Model
2011 Jan 1;17(3):543-53
PMID: 20512604
Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice.
Fu Z, Zhang W, Zhen W, Lum H, Nadler J, Bassaganya-Riera J, Jia Z, Wang Y, Misra H, Liu D.
Endocrinology
2010 Jan 1;151(7):3026-37
PMID: 20484465
Immunoregulatory actions of epithelial cell PPAR gamma at the colonic mucosa of mice with experimental inflammatory bowel disease.
Mohapatra SK, Guri AJ, Climent M, Vives C, Carbo A, Horne WT, Hontecillas R, Bassaganya-Riera J
PLoS One
2010 Apr 20;5(4)
PMID: 20422041
Model of colonic inflammation: immune modulatory mechanisms in inflammatory bowel disease.
Wendelsdorf K, Bassaganya-Riera J, Hontecillas R, Eubank S.
J Theor Biol
2010 Jan 1;264(4):1225-39
PMID: 20362587
Abscisic acid synergizes with rosiglitazone to improve glucose tolerance and down-modulate macrophage accumulation in adipose tissue: possible action of the cAMP/PKA/PPAR ? axis.
Guri AJ, Hontecillas R, Bassaganya-Riera J.
Clin Nutr
2010 Oct 1;29(5):646-53
PMID: 20207056
Abscisic acid ameliorates atherosclerosis by suppressing macrophage and CD4+ T cell recruitment into the aortic wall.
Guri AJ, Misyak SA, Hontecillas R, Hasty A, Liu D, Si H, Bassaganya-Riera J.
J Nutr Biochem
2010 Jan 1;21(12):1178-85
PMID: 20092994
Modulation of hepatic PPAR expression during Ft LVS LPS-induced protection from Francisella tularensis LVS infection.
Mohapatra SK, Cole LE, Evans C, Sobral BW, Bassaganya-Riera J, Hontecillas R, Vogel SN, Crasta OR.
BMC Infect Dis.
Jan 18
PMID: 20082697
Deletion of PPAR-y in immune cells enhances susceptibility to antiglomerular basement membrane disease.
Chafin C, Muse S, Hontecillas R, Bassaganya-Riera J, Caudell DL, Shimp SK 3rd, Rylander MN, Zhang J, Li L, Reilly CM.
J Inflamm Res3
2010 Jan 1;3:127-34
PMID: 22096362
Mechanisms of action and medicinal applications of abscisic Acid.
Bassaganya-Riera J, Skoneczka J, Kingston DG, Krishnan A, Misyak SA, Guri AJ, Pereira A, Carter AB, Minorsky P, Tumarkin R, Hontecillas R.
Curr Med Chem
2010 Jan 1;17(5):467-78
PMID: 20015036
Early evidence of increased risk for metabolic syndrome in young men with latent obstructive sleep apnea.
Guill S, Hargens T, Nickols-Richardson S, Bassaganya-Riera J, Miller L, Zedalis D, Gregg J, Gwazdauskas F, Herbert W.
Metab Syndr Relat Disord
2010 Feb 1;8(1):33-8
PMID: 19943797
Green tea extract decreases muscle pathology and NF-kappaB immunostaining in regenerating muscle fibers of mdx mice.
Evans NP, Call JA, Bassaganya-Riera J, Robertson JL, Grange RW.
Clin Nutr
2010 Jun 1;29(3):391-8
PMID: 19897286
Virtual Screening as a Technique for PPAR Modulator Discovery.
Lewis SN, Bassaganya-Riera J, Bevan DR.
PPAR Res
2010 Jan 1
PMID: 19746174
Peroxisome proliferator-activated receptor gamma is required for regulatory CD4+ T cell-mediated protection against colitis.
Hontecillas R, Bassaganya-Riera J.
J Immunol.
2007 Mar 1;178(5):2940-9
PMID: 17312139
Peroxisome proliferator-activated receptors: bridging metabolic syndrome with molecular nutrition.
Guri AJ, Hontecillas R, Bassaganya-Riera J.
Clin Nutr.
2006 Dec 1;25(6):871-85
PMID: 17052808
Impact of immunizations with porcine reproductive and respiratory syndrome virus on lymphoproliferative recall responses of CD8+ T cells.
Bassaganya-Riera J, Thacker BJ, Yu S, Strait E, Wannemuehler MJ, Thacker EL.
Viral Immunol.
2004 Jan 1;17(1):25-37
PMID: 15018660